Endocrine disorders in chronic kidney disease

The increasing prevalence of chronic kidney disease gives rise to many diagnostic challenges in the daily care this group patients. This paper presents most clinically significant endocrine disorders accompanying disease, their aetiology, diagnosis, clinical picture and treatment. Endocrine may occur patients with greater or equal frequency as general population. important include: low triiodothyronine syndrome, subclinical overt hypothyroidism, hypercortisolaemia, hyperprolactinaemia, increased levels growth hormone, hyperinsulinaemia, insulin resistance hypogonadism. Hyperthyroidism autoimmune thyroid same Chronic also affects commonly used hormone determinations. choice therapeutic method is not without importance for disorders. Among undergoing dialysis therapy, a temporary increase free hormones, decrease severity hypercortisolaemia were observed. Dialysis therapy does normalise prolactin levels, unlike transplantation, where an improvement glomerular filtration rate results normalisation serum prolactin. management some presented based on causal effect, but mainly controlling complications (e.g. secondary – hypertension, diabetes, osteopenia abdominal obesity). In remaining cases, replacement was associated beneficial effect patient: testosterone obese men hypogonadism led body mass index, cyclical transdermal women oestrogen deficiency renal failure inhibited bone demineralisation thus prevented early osteoporosis.